Toshihisa Kawai Selected Research

Alveolar Bone Loss

12/2020	Protective effects of desipramine on alveolar bone in experimental periodontitis.
10/2020	Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.
1/2018	OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9.
8/2017	Different engagement of TLR2 and TLR4 in Porphyromonas gingivalis vs. ligature-induced periodontal bone loss.
1/2017	IL-21/anti-Tim1/CD40 ligand promotes B10 activity in vitro and alleviates bone loss in experimental periodontitis in vivo.
1/2017	Local Induction of B Cell Interleukin-10 Competency Alleviates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice.
11/2016	A novel method of sampling gingival crevicular fluid from a mouse model of periodontitis.
5/2012	Fluoxetine inhibits inflammatory response and bone loss in a rat model of ligature-induced periodontitis.
9/2009	PPAR-gamma agonist rosiglitazone prevents inflammatory periodontal bone loss by inhibiting osteoclastogenesis.
12/2004	The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss.

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Toshihisa Kawai Research Topics

Disease

25	Bone Resorption 05/2022 - 01/2004
22	Periodontitis 05/2022 - 05/2007
18	Periodontal Diseases (Periodontal Disease) 11/2020 - 11/2003
15	Inflammation (Inflammations) 01/2021 - 01/2007
11	Alveolar Bone Loss 12/2020 - 01/2004
11	Infections 10/2020 - 12/2004
3	Necrosis 01/2019 - 11/2003
3	Periapical Periodontitis (Apical Periodontitis) 10/2018 - 06/2017
2	Arthritis (Polyarthritis) 10/2020 - 11/2018
2	Rheumatoid Arthritis 11/2016 - 01/2013
1	Neoplasms (Cancer) 05/2021
1	Dental Pulp Necrosis 05/2021
1	Experimental Arthritis 10/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2020
1	Surgical Wound 01/2018
1	Osteonecrosis (Kienbock's Disease) 11/2016
1	Multiple Sclerosis 11/2016

Drug/Important Bio-Agent (IBA)

10	CytokinesIBA 01/2021 - 11/2003
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017 - 11/2003
6	LigandsIBA 11/2016 - 11/2005
5	Interleukin-6 (Interleukin 6)IBA 01/2021 - 11/2003
5	Messenger RNA (mRNA)IBA 01/2019 - 01/2004
4	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2021 - 10/2014
4	Proteins (Proteins, Gene)FDA Link 10/2020 - 01/2014
4	Interleukin-10 (Interleukin 10)IBA 01/2017 - 12/2004
3	CollagenIBA 12/2020 - 05/2012
3	Virulence Factors (Pathogenicity Factors)IBA 01/2020 - 11/2003
3	Tartrate-Resistant Acid PhosphataseIBA 01/2018 - 10/2016
3	EnzymesIBA 11/2016 - 12/2004
3	OsteoprotegerinIBA 05/2007 - 11/2005
3	kaliotoxinIBA 11/2005 - 01/2004
3	AntigensIBA 11/2005 - 01/2004
2	CD100 antigenIBA 05/2022 - 11/2016
2	laminaranIBA 10/2020 - 11/2018
2	dihydroceramideIBA 01/2020 - 05/2017
2	Macrophage Migration-Inhibitory FactorsIBA 01/2019 - 10/2017
2	Polymethyl Methacrylate (Sol)IBA 01/2019 - 01/2016
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 04/2018 - 06/2017
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 04/2018 - 06/2017
2	Protein Isoforms (Isoforms)IBA 01/2018 - 12/2004
2	Silk FDA Link 01/2017 - 11/2016
2	CD40 Ligand (CD40L)IBA 01/2017 - 01/2017
2	AutoantibodiesIBA 08/2013 - 01/2013
2	Interleukin-8 (Interleukin 8)IBA 01/2012 - 01/2010
2	PPAR gammaIBA 09/2009 - 01/2008
2	HydrogenIBA 08/2009 - 08/2009
2	AntioxidantsIBA 08/2009 - 08/2009
2	ImmunosorbentsIBA 08/2007 - 12/2004
2	InterleukinsIBA 08/2007 - 11/2003
2	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 05/2007 - 09/2006
2	Scorpion Venoms (Scorpion Venom)IBA 11/2005 - 11/2005
2	Potassium Channels (Potassium Channel)IBA 11/2005 - 11/2005
2	RANK LigandIBA 11/2005 - 11/2005
1	SeleniumIBA 05/2021
1	Pemetrexed (MTA)FDA Link 04/2021
1	mineral trioxide aggregateIBA 04/2021
1	LipopolysaccharidesIBA 01/2021
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 12/2020
1	C.I. direct red 80IBA 12/2020
1	Desipramine (Pertofrane)FDA LinkGeneric 12/2020
1	Matrix Metalloproteinases (MMPs)IBA 12/2020
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 11/2020
1	Biocompatible Materials (Biomaterials)IBA 11/2020
1	Thymic Stromal LymphopoietinIBA 11/2020
1	Protein-Arginine DeiminasesIBA 10/2020
1	SphingolipidsIBA 01/2020
1	CeramidesIBA 01/2020
1	CXCR4 Receptors (CXCR4 Receptor)IBA 01/2019
1	ChemokinesIBA 01/2019
1	Bone Cements (Bone Glue)IBA 01/2019
1	Toll-Like Receptor 4IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 11/2018
1	Dental MaterialsIBA 10/2018
1	MicroRNAs (MicroRNA)IBA 03/2018
1	CeramidasesIBA 01/2018
1	Coloring Agents (Dyes)IBA 01/2018
1	AlbuminsIBA 01/2018
1	Evans Blue (Blue, Evans)FDA Link 01/2018
1	Acid CeramidaseIBA 01/2018
1	Hydrocortisone (Cortisol)FDA LinkGeneric 10/2017
1	CorticosteroneIBA 10/2017
1	GlucocorticoidsIBA 10/2017
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 10/2017
1	LipidsIBA 05/2017
1	GuanosineIBA 01/2017
1	CytidineIBA 01/2017
1	Phosphates (Orthophosphate)IBA 01/2017
1	Toll-Like Receptor 9IBA 01/2017
1	interleukin-21 (interleukin 21)IBA 01/2017
1	OligodeoxyribonucleotidesIBA 01/2017
1	Biological ProductsIBA 11/2016
1	Phosphotransferases (Kinase)IBA 02/2016
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 02/2016
1	Tissue Inhibitor of MetalloproteinasesIBA 02/2016
1	Monoclonal AntibodiesIBA 01/2016

Therapy/Procedure

15	Ligation 05/2022 - 09/2009
4	Therapeutics 11/2020 - 01/2004
1	Intraperitoneal Injections 11/2018
1	Endodontics 10/2018
1	Endoscopes 01/2018